553031

RAGE Antagonist Peptide, RAP

The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE.

• 別名: RAGE Antagonist Peptide, RAP, ELKVLMEKEL
• 実験式（ヒル表記法）: C₅₇H₁₀₁N₁₃O₁₇S
• 分子量: 1272.55
• UNSPSCコード: 12352111
• NACRES: NA.77

特性

• 品質水準: 200
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 有効性: 2 μM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 5 mg/mL
• 輸送温度: dry ice
• 保管温度: −20°C

詳細

詳細

An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.

生物化学的／生理学的作用

Primary Target
RAGE

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-ELKVLMEKEL-NH2

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable