539749

PTP1B Inhibitor

InSolution, ≥97%

• 別名: InSolution PTP1B Inhibitor, PTP Inhibitor XXII
• 実験式（ヒル表記法）: C₂₆H₁₉Br₂N₃O₇S₃
• 分子量: 741.45
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: liquid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B₄₀₃ and PTP1B₂₉₈, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.

生物化学的／生理学的作用

Cell permeable: yes

IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively

Reversible: yes

包装

Packaged under inert gas

警告

Toxicity: Irritant (B)

物理的形状

A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.

再構成

Following initial thaw, aliquot and freeze (-20°C).

その他情報

Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• 引火点(℃): 87 °C - closed cup - (Dimethylsulfoxide)