5.04914

CNQX

• 別名: CNQX, 6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline
• 実験式（ヒル表記法）: C₉H₄N₄O₄
• CAS番号: 115066-14-3
• 分子量: 232.15
• MDL番号: MFCD00069232
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: off-white to yellow
• 溶解性: DMSO: 25 mg/mL
• 保管温度: 2-8°C
• InChI: 1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
• InChI Key: RPXVIAFEQBNEAX-UHFFFAOYSA-N

詳細

詳細

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

A potent and competitive antagonist for AMPA/kainate receptors (K_i = 0.6 - 2.11 µM for GluA1-4 and K_i = 1.3-5.3 µM for different subtypes of Kainate receptors) and a negative allosteric modulator at NMDA receptor glycine binding site. Widely used for assessing the functional roles of neurotransmission mediated by glutamate receptors in both normal and abnormal brain functions.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生物化学的／生理学的作用

Secondary Target
Kainate

Target K_i: 0.6 – 2.11 →M for GluA1 – 4 and Ki

警告

Toxicity: Standard Handling (A)

その他情報

Lee, S., et al. 2010. J. Neurophysiol.103, 1728.
King, A., et al. 1992. Br. J. Pharmacol.107, 375.
Long, S. et al. 1990. Br. J. Pharmacol.100, 850.Harris, K., et al. 1989. Brain Res.5, 185Honore, T., et al. 1988. Science.241, 701.Birch, P., et al. 1988. Eur. J. Pharmacol.156, 177.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable