475882-M

ML-9, Hydrochloride

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM).

• 別名: ML-9, Hydrochloride, 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
• 実験式（ヒル表記法）: C₁₅H₁₇ClN₂O₂S · xHCl
• CAS番号: 105637-50-1
• 分子量: 324.83 (free base basis)
• MDL番号: MFCD00065525
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: white
• 溶解性: 50% ethanol: 10 mg/mL
• 保管温度: 2-8°C
• SMILES記法: [S](=O)(=O)(N3CCNCCC3)c1c2c(c(ccc2)Cl)ccc1.[Cl-].[H+]
• InChI: 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H
• InChI Key: ZNRYCIVTNLZOGI-UHFFFAOYSA-N

詳細

詳細

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (K_i = 3.8 µM), protein kinase A (K_i = 32 µM), and protein kinase C (K_i = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.

生物化学的／生理学的作用

Primary Target
Mlck

Target K_i: 3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively

警告

Toxicity: Standard Handling (A)

調製ノート

Further dilute with aqueous buffer just prior to use.

再構成

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

その他情報

Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun.143, 1045.
Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun.140, 280.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable