412510

IRE1 Inhibitor I, STF-083010

The IRE1 Inhibitor I, STF-083010 controls the biological activity of IRE1. This small molecule/inhibitor is primarily used for Biochemicals applications.

• 別名: IRE1 Inhibitor I, STF-083010, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, N-[(2-Hydroxynaphthalen-1-yl)methylidene]thiophene-2-sulfonamide, N-[(2-Hydroxy-1-naphthyl)methylene]-2-thiophenesulfonamide, ER-to-Nucleus Signaling 1 Inhibitor I, ERN1 Inhibitor I, Inositol-Reguiring Protein 1 Inhibitor I, STF083010
• 実験式（ヒル表記法）: C₁₅H₁₁NO₃S₂
• 分子量: 317.38
• MDL番号: MFCD02332975
• UNSPSCコード: 51111800
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: yellow
• 溶解性: DMSO: 100 mg/mL, clear, yellow
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: [S](=O)(=O)(\N=C\c2c3c(ccc2O)cccc3)c1[s]ccc1
• InChI: 1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
• InChI Key: TVIVJHZHPKNDAQ-MHWRWJLKSA-N

詳細

詳細

A cell-permeable salicylidene compound that is shown to directly target Ireα1 and disrupt Ire1-XBP1 (X-box binding protein) unfolded protein response (UPR) pathway in RPMI8226 multiple myeloma (MM) cells. Selectively inhibits ER stress-initiated endonuclease activity of Ire1 and blocks XPB1 mRNA splicing in MM cells at 60 µM and XBP1 activity in transgenic XBP1-luc mice (bortezomib 1mg/kg and 60 mg/kg of STF-083010, i.p.). Displays preferential cytotoxicity towards CD138+ cells over B, T and NK cells and antitumor properties.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

再構成

Unstable in solution; reconstitute just prior to use.

その他情報

Lerner, A.G., et al. 2012 Cell Metabolism16, 250.
Papandreou, I., et al. 2010. Blood117, )1311.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable