368067-M

Granzyme B Substrate VIII, Colorimetric

A colorimetric substrate for granzyme B (kcat/Km = 6.6 x 10⁴ M⁻¹s⁻¹).

• 別名: Granzyme B Substrate VIII, Colorimetric, Ac-IEPD- pNA
• 実験式（ヒル表記法）: C₂₈H₃₈N₆O₁₁
• 分子量: 634.63
• UNSPSCコード: 12352200
• PubChem Substance ID: 2826717

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 保管温度: −20°C
• SMILES記法: CCC(C)C(C(=O)NC(CCC(=O)O)C(=O)N1CCCC1C(=O)NC(CC(=O)O)C(=O)NC2=CC=C(C=C2)[N+](=O)[O-])NC(=O)C
• InChI Key: YXEIIOVAGGAMCZ-UHFFFAOYSA-N

詳細

詳細

A colorimetric substrate for granzyme B (k_cat/K_m = 6.6 x 10⁴ M^-1s^-1). Cleavage of pNA is monitored colorimetrically at ~405 nm (ε = 9,160 M^-1cm^-1).

生物化学的／生理学的作用

Primary Target
Colorimetric substrate for granzyme B

kcat/Km = 6.6 x 104 M⁻¹ sec⁻¹ as substrate for granzyme B

警告

Toxicity: Standard Handling (A)

シーケンス

Ac-Ile-Glu-Pro-Asp-pNA

再構成

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Harris, J.L., et al. 1998. J. Biol. Chem. 273, 27364.
Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable