344931-M

Furin Inhibitor II

The Furin Inhibitor II controls the biological activity of Furin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Furin Inhibitor II, Hexa-D-arginine, H-(D)RRRRRR-NH₂
• 実験式（ヒル表記法）: C₃₆H₇₅N₂₅O₆
• 分子量: 954.14
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: water: 1 mg/mL; DMSO: soluble
• 保管温度: −20°C

詳細

詳細

A polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.

A polyarginine that acts as a potent, specific, and competitive inhibitor of furin (K_i = 106 nM). Inhibits subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (K_i = 580 nM and 13 µM, respectively). Does not affect the activity of PC2. The D-peptides are suggested to be more resistant to in vivo hydrolysis than the L-peptides.

生物化学的／生理学的作用

Primary Target
furin

Target K_i: 106 nM against Furin

警告

Toxicity: Standard Handling (A)

シーケンス

H-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Cameron, A., et al. 2000. J. Biol. Chem.275, 36741.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable