341251

Fascaplysin, Synthetic

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM).

• 別名: Fascaplysin, Synthetic
• 実験式（ヒル表記法）: C₁₈H₁₁ClN₂O
• CAS番号: 114719-57-2
• 分子量: 306.75
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥98% (NMR)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic); protect from light
• 色: brown
• 溶解性: methanol: 1 mg/mL; DMSO: 10 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C18H10N2O.ClH/c21-18-13-6-2-4-8-15(13)20-10-9-12-11-5-1-3-7-14(11)19-16(12)17(18)20;/h1-10H;1H
• InChI Key: PWUOOJVYZQILBG-UHFFFAOYSA-N

詳細

詳細

A cell-permeable red pigment, originally isolated from a species of marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/cyclin D1 (IC₅₀ = 350 nM). Reported to inhibit Cdk6/cyclin D1 with much lower potency (IC₅₀ = 3.4 µM). Exhibits little to no effect on the activities of several other Cdk′s (IC₅₀ >20 µM) and tyrosine kinases (IC₅₀ >10 µM). Biological effects are attributed, in part, to its ability to intercalate into DNA. Also displays anti-microbial activity.

A cell-permeable red pigment, originally isolated from marine sponge, that acts as a potent, ATP-competitive inhibitor of Cdk4/D1 (IC₅₀ = 0.35 µM). It inhibits Cdk6/D1 with much lower potency (IC₅₀ = 3.4 µM) and has been shown not to affect the activities of several other Cdk’s (IC₅₀ >20 µM) and tyrosine kinases (IC₅₀ >10 µM). Part of its biological effects may also be attributed to its ability to intercalate into DNA. Has also been shown to display anti-microbial activity.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
CDK4/D1

Product competes with ATP.

Reversible: yes

Target IC₅₀: 0.35 µM against Cdk4/D1

包装

Packaged under inert gas

警告

Toxicity: Toxic (F)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Hormann, A., et al. 2001. Bioorg. Med. Chem.9, 917.
Kirsch, G., et al. 2000. J. Nat. Prod.63, 825.
Soni, R., et al. 2000. Biochem. Biophys. Res. Commun.275, 877.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable