287815

3,4-Dichloroisocoumarin

• 別名: 3,4-Dichloroisocoumarin
• 実験式（ヒル表記法）: C₉H₄Cl₂O₂
• CAS番号: 51050-59-0
• 分子量: 215.03
• MDL番号: MFCD00036960
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥99% (elemental analysis)
• 品質水準: 100
• 形状: lyophilized solid
• 有効性: 5-100 μM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated
• 色: white
• 溶解性: DMF: 10 mM; DMSO: 10 mM
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C9H4Cl2O2/c10-7-5-3-1-2-4-6(5)9(12)13-8(7)11/h1-4H
• InChI Key: SUGXUUGGLDCZKB-UHFFFAOYSA-N

詳細

詳細

A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 µM.

A potent, irreversible inhibitor of serine proteases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Inhibits granzyme B and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Does not affect thiol proteases and metalloproteases. Does not exhibit any activity towards β-lactamases.

Effective concentration: 5-100 µM; t_½ = 20 min at pH 7.5.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
serine proteases

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Cain, K., et al. 1994. Biochem. Cell Biol.72, 631.
Weaver, V.M., et al. 1993. Biochem. Cell Biol. 71, 488.
Odake, S., et al. 1991. Biochemistry 30, 2217.
Harper, J.W., et al. 1985. Biochemistry24, 1831.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H301,H315,H319,H335
• 注意書き: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• ターゲットの組織: Respiratory system
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable