220467

2-Chloro-2′-deoxyadenosine

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity.

• 別名: 2-Chloro-2′-deoxyadenosine, 2CdA, Cladribine
• 実験式（ヒル表記法）: C₁₀H₁₂ClN₅O₃
• CAS番号: 4291-63-8
• 分子量: 285.69
• MDL番号: MFCD00153939
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• InChI: 1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1
• InChI Key: PTOAARAWEBMLNO-KVQBGUIXSA-N

詳細

詳細

A deoxyadenosine analog that displays strong antileukemic and immunosuppressive activity. Also induces apoptosis in chronic lymphocytic leukemia (CLL) cells.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Antileukemic and immunosuppressive activity

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

その他情報

Bellosillo, B., et al. 1997. Blood 89, 3378; Bryson, H.M., and Sorkin, E.M. 1993. Drugs 46, 872.
Robertson, L.E., et al. 1993. Blood81, 143.
Carson, D.A., et al. 1988. Adv. Enzyme Regul. 27, 395.
Carson, D.A., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 2232.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H301,H341,H361fd,H372
• 注意書き: P202 - P260 - P264 - P280 - P301 + P310 - P405
• 危険有害性の分類: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• 保管分類コード: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable