219381

Cathepsin K Inhibitor III

The Cathepsin K Inhibitor III controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 別名: Cathepsin K Inhibitor III, Inhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂
• 実験式（ヒル表記法）: C₃₀H₄₃N₇O₆
• 分子量: 597.71
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: lyophilized solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 色: white
• 溶解性: DMSO: 1 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

詳細

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.

A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
Cathepsin K

Product does not compete with ATP.

Reversible: yes

Target K_i: 9.7 nM against cathepsin K

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

シーケンス

H-Phe-Leu-NHNH-CO-NHNH-Leu-Z

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Wang, D., et al. 2002. Biochemistry41, 8849.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable