203988

Butyrolactone I

A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G₁/S and G₂/M transitions.

• 別名: Butyrolactone I
• 実験式（ヒル表記法）: C₂₄H₂₄O₇
• CAS番号: 87414-49-1
• 分子量: 424.44
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥99% (TLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 輸送温度: ambient
• 保管温度: −20°C
• InChI: 1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1
• InChI Key: FPVUCBMBMUHRDX-XMMPIXPASA-N

詳細

詳細

A cell-permeable and highly selective inhibitor of cyclin-dependent protein kinases (Cdks) that inhibits cell cycle progression at the G₁/S and G₂/M transitions. Inhibits p34^cdk1/cyclinB (Cdk1; IC₅₀ = 680 nM). Also selectively inhibits Cdk2 and Cdk5 kinases. Has little effect on casein kinase I, casein kinase II, EGF receptor kinase, MAP kinase, PKA, and PKC. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Also blocks Fas-induced apoptosis in HL-60 cells and shows antitumor effects on human lung cancer cell lines.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
p34cdk1/cyclinB

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 680 nM against Cdk1

警告

Toxicity: Standard Handling (A)

再構成

Following initial thaw, aliquot and freeze (-20°C).

その他情報

Furukawa, Y., et al. 1996. J. Biol. Chem. 271, 28469.
Nishio, K., et al. 1996. Anticancer Res. 16, 3387.
Kitagawa, M., et al. 1994. Oncogene 9, 2549.
Kitagawa, M., et al. 1993. Oncogene 8, 2425.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable