189410

Aurora Kinase Inhibitor VI, ZM447439

The Aurora Kinase Inhibitor VI, ZM447439, also referenced under CAS 331771-20-1, controls the biological activity of Aurora Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Aurora Kinase Inhibitor VI, ZM447439, 4-(4-(N-Benzoylamino)anilino)-6-methoxy-7-(3-(1-morpholino)propoxy)quinazoline
• 実験式（ヒル表記法）: C₂₉H₃₁N₅O₄
• CAS番号: 331771-20-1
• 分子量: 513.59
• MDL番号: MFCD08703125
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• フォーム: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 50 mg/mL
• 輸送温度: ambient
• 保管温度: 2-8°C
• SMILES記法: O=C(C1=CC=CC=C1)NC(C=C2)=CC=C2NC3=NC=NC4=C3C=C(OC)C(OCCCN5CCOCC5)=C4
• InChI: 1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
• InChI Key: OGNYUTNQZVRGMN-UHFFFAOYSA-N

詳細

詳細

A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC₅₀ = 110 and 130 nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC₅₀ = 0.88, 1.03 and 1.79 µM for Lck, Src and MEK1, respectively, and IC₅₀ >10 µM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser¹⁰ in Xenopus cycling egg extracts at 20 µM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells.

包装

Packaged under inert gas

警告

Toxicity: Regulatory Review (Z)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Gadea, B.B. and Ruderman, J.V., 2005. Mol. Biol. Cell16, 1305.
Ditchfield, C., et al. 2003. J. Cell Biol.161, 267.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable