171601

Amyloid Precursor Protein β-Secretase Inhibitor

The Amyloid Precursor Protein β-Secretase Inhibitor controls the biological activity of Amyloid Precursor Protein β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

• 別名: Amyloid Precursor Protein β-Secretase Inhibitor, KTEETSEVN(stat)VAEF
• 実験式（ヒル表記法）: C₇₃H₁₁₈N₁₆O₂₇
• 分子量: 1651.81
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: lyophilized
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: aqueous buffer, pH 7.5: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A potent inhibitor of the amyloid precursor protein (APP) β-secretase (IC₅₀ = 30 nM).

生物化学的／生理学的作用

Cell permeable: no

Primary Target
APP

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM against amyloid precursor protein (APP) β-secretase

警告

Toxicity: Standard Handling (A)

シーケンス

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Stat-Val-Ala-Glu-Phe-OH [Stat = (3S,4S)-Statine]

物理的形状

Supplied as a trifluoroacetate salt.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Sinha, S., et al. 1999. Nature 402, 537.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable