165350

PARP Inhibitor I, 3-ABA

The PARP Inhibitor I, 3-ABA, also referenced under CAS 3544-24-9, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 別名: PARP Inhibitor I, 3-ABA, 3-Aminobenzamide
• 実験式（ヒル表記法）: C₇H₈N₂O
• CAS番号: 3544-24-9
• 分子量: 136.15
• MDL番号: MFCD00007989
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥99% (GC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: ethanol: 1 mg/mL; water: 1 mg/mL; DMSO: 5 mg/mL
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C7H8N2O/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,8H2,(H2,9,10)
• InChI Key: GSCPDZHWVNUUFI-UHFFFAOYSA-N

詳細

詳細

A cell-permeable anti-proliferative agent that acts as an inhibitor of poly(ADP-ribose) polymerase (PARP). Has minimal effect on bacterial toxin-mediated ADP-ribosylation. An inhibitor of UV-induced apoptosis. Also strongly inhibits K562 target cell killing by human effector natural killer cells.

生物化学的／生理学的作用

Cell permeable: yes

Primary Target
PARP

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Irritant (B)

再構成

Following reconstitution, aliquot and freeze (-20°C ). Stock solutions are stable for 3 months at -20°C.

その他情報

Tiozzo, R., et al. 1996. Biochem. Biophys. Res. Commun. 225, 826.
Malorni, W., et al. 1995. Biochem. Biophys. Res. Commun. 207, 715.
Malorni, W., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1250.
Monti, D., et al. 1994. Biochem. Biophys. Res. Commun.199, 525.
Kozak, K.R., and Ross, I.A. 1991. Biochem. Biophys. Res. Commun.179, 1225.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3