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由来生物
human
品質水準
リコンビナント
expressed in baculovirus infected Sf21 cells
分子量
Mw 63.8 kDa
メーカー／製品名
Upstate®
テクニック
activity assay: suitable (kinase)
NCBIアクセッション番号
UniProtアクセッション番号
詳細
Research area: CELL SIGNALING
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
Product Source: expressed by baculovirus in Sf21 cells
The anaplastic lymphoma kinase (ALK) is a member of the insulin receptor superfamily of receptor tyrosine kinases. The ALK gene is located on human chromosome 2p23 and shares a high similarity with the leukocyte tyrosine kinase (Ltk). ALK is composed of three domains: an extracellular domain responsible for ligand binding, a transmembrane domain that spans the cell membrane, and a cytoplasmic domain housing the tyrosine kinase activity. The cytoplasmic tyrosine kinase domain of ALK plays a significant role in disease pathologies associated with the gene. Within the structure, there are two short conserved β-strands (β7-β8) housing majority of the catalytic residues. Full-length ALK is specifically expressed in the developing central and peripheral nervous systems during embryogenesis and is associated with the balance of cell proliferation and differentiation.
アプリケーション
Research Category
Inflammation & Immunology
Inflammation & Immunology
生物化学的／生理学的作用
Protein Target: ALK
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
Target Sub-Family: TK Anaplastic lymphoma kinase (ALK) plays a crucial role in the development of neurons. Binding of ligand to its extracellular domain triggers the activation of the tyrosine kinase that in turn activates the mitogen-activated protein kinase (MAPK) pathway. ALK fusion proteins induce the activation of diverse pathways including Phospholipase C gamma (PLC-γ) and Ras/Extracellular Signal-Regulated Kinase 1/2 (Ras/ERK1/2), which contribute to cell proliferation, while the Janus Kinase/signal transducer and activator of transcription (JAK/STAT) pathway and Phosphoinositide 3-kinase/Protein Kinase B (PI3K/Akt) pathways facilitate cell survival. Notably, ALK has been found to be overexpressed in various human tumors and cell lines such as lymphomas, neuroblastoma, and non-small-cell lung cancer.
品質
routinely evaluated by phosphorylation of IGF-1Rtide
物理的形状
Ni2+/NTA-agarose
保管および安定性
6 months at -70°C from date of shipment
その他情報
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Expression of anaplastic lymphoma kinase in non-Hodgkin's lymphomas and other malignant neoplasms. Biological, diagnostic, and clinical implications.
Wasik, Mariusz A
American Journal of Clinical Pathology, 118 Suppl, S81-S92 (2002)
K Pulford et al.
Cellular and molecular life sciences : CMLS, 61(23), 2939-2953 (2004-12-08)
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase, the normal role of which remains to be completely elucidated. Although work carried out in mammals suggests a function in neural development, results from studies in Drosophila indicate an additional role
Anaplastic lymphoma kinase proteins in growth control and cancer.
Pulford, K, et al.
Journal of Cellular Physiology, 199, 330-358 (2004)
ALK a novel lymphoma-associated tumor antigen for vaccination strategies.
Passoni, Lorena and Gambacorti-Passerini, Carlo
Leukemia & Lymphoma, 44, 1675-1681 (2003)
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