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由来生物
human
品質水準
リコンビナント
expressed in baculovirus infected Sf21 cells
分子量
Mw 67.2 kDa
メーカー／製品名
Upstate®
テクニック
activity assay: suitable (kinase)
NCBIアクセッション番号
UniProtアクセッション番号
詳細
N-terminal GST-tagged recombinant human B-Raf residues 416-end
Product Source: Expressed by baculovirus in Sf21 insect cells
アプリケーション
Research Category
代謝
炎症及び免疫
代謝
炎症及び免疫
Research Sub Category
肥満
代謝障害
骨粗しょう症
関節炎
肥満
代謝障害
骨粗しょう症
関節炎
生物化学的／生理学的作用
Protein Target: B-Raf
Target Sub-Family: TKL
包装
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-530M when ordering the 250 µg size.
品質
routinely evaluated by phosphorylation of MBP substrate in vitro
物理的形状
Glutathione agarose affinity chromatography
保管および安定性
6 months at -70°C
その他情報
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法的情報
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Vanessa C Gray-Schopfer et al.
Cancer metastasis reviews, 24(1), 165-183 (2005-03-24)
Melanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. If detected early, it is easily treated by surgical excision. However, once melanoma metastasises it is notoriously resistant to
Mathew J Garnett et al.
Cancer cell, 6(4), 313-319 (2004-10-19)
RAF proteins are components of a conserved signaling pathway that regulates cellular responses to extracellular signals. Despite over 20 years of research into the regulation and function of the RAF proteins, it was only realized recently that the B-RAF isoform
Stevan R Hubbard
Cell, 116(6), 764-766 (2004-03-24)
A study by Wan et al. in this issue of Cell demonstrates that the majority of oncogenic mutations in the B-Raf protein kinase result in increased catalytic activity, through disruption of the autoinhibited state of the kinase domain. Surprisingly, several
Kathryn E Mercer et al.
Biochimica et biophysica acta, 1653(1), 25-40 (2003-06-05)
A recent report has shown that activating mutations in the BRAF gene are present in a large percentage of human malignant melanomas and in a proportion of colon cancers. The vast majority of these mutations represent a single nucleotide change
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