07-2054
Anti-MBD1 Antibody, CT
from rabbit
別名:
CXXC-type zinc finger protein 3, Methyl-CpG-binding protein MBD1, Protein containing methyl-CpG-binding domain 1, methyl-CpG binding domain protein 1, methyl-CpG binding domain protein 1 isoform PCM1, the regulator of fibroblast growth factor 2 (FGF-2) <
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About This Item
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由来生物
rabbit
品質水準
抗体製品タイプ
primary antibodies
クローン
polyclonal
化学種の反応性
human
テクニック
ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PCM1(5108)
詳細
DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, regulates gene expression and is critical for proper development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has been shown to play a role in chromatin modification through interaction with the histone H3K9 methyltransferase SETDB1. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that each contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. MBD1, MBD2, MBD3, and MBD4 are expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity.
特異性
Not tested in other species.
This antibody recognizes human MBD1.
免疫原
Epitope: C-terminus
The immunogen was a KLH-conjugated synthetic peptide corresponding the C-terminal region of human MBD1.
アプリケーション
Research Category
エピジェネティクス及び核内機能分子
エピジェネティクス及び核内機能分子
Research Sub Category
エピジェネティクス
エピジェネティクス
Anti-MBD1 Antibody, C-terminus is a Rabbit Polyclonal Antibody for detection of MBD1 also known as CXXC-type zinc finger protein 3 & has been validated in WB, ELISA.
ELISA:
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).
This antibody has been shown by an outside laboratory to be suitable for ELISA (1:1000).
品質
Western Blot Analysis:
This antibody recognizes MBD1 on 10 µg of HeLa cell lysate.
This antibody recognizes MBD1 on 10 µg of HeLa cell lysate.
ターゲットの説明
~61 kDa
物理的形状
Protein G Chromatography
Format: Purified
Purified rabbit polyclonal in buffer containing 0.09% NaN3.
保管および安定性
Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
アナリシスノート
Control
HeLa cell lysate
HeLa cell lysate
その他情報
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 2
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
07-2054:
試験成績書(COA)
製品のロット番号・バッチ番号を入力して、試験成績書(COA) を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
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