07-1801

Anti-G3BP1 Antibody

serum, from rabbit

• 別名: ATP-dependent DNA helicase VIII, GAP SH3 domain-binding protein 1, GAP binding protein, GTPase activating protein (SH3 domain) binding protein 1, Ras-GTPase-activating protein SH3-domain-binding protein, RasGAP-associated endoribonuclease G3BP
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 抗体製品の状態: serum
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: mouse, human
• 化学種の反応性（ホモロジーによる予測）: rat (100% immunogen homology)
• テクニック: immunoprecipitation (IP): suitable; western blot: suitable
• NCBIアクセッション番号: NP_005745
• UniProtアクセッション番号: Q13884
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... G3BP1(10146) ; mouse ... G3Bp1(27041)

詳細

詳細

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.

特異性

Not tested on other species.

This antibody detects G3BP1 at its C-terminal region.

免疫原

Epitope: C-terminus

Synthetic peptide corresponding to C-terminal region of human G3BP1.

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
RNA結合タンパク質（RBP）

Anti-G3BP1 Antibody detects level of G3BP1 & has been published & validated for use in WB & IP.

品質

Evaluated by western blot on HeLa cell lysates.

Western Blot Analysis:
1:1,000 dilution of this antibody was used to detect G3BP1 in HeLa, 293T and S10 cell lysates.

ターゲットの説明

68 kDa

物理的形状

Rabbit polyclonal serum with 0.05% NaN3.

保管および安定性

Stable for 1 year at -20ºC from date of receipt.

アナリシスノート

Control
HeLa cell lysates.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1