05-23-3801

Endothelin 3, Human and Rat

Attenuates thrombin-evoked aggregation of human platelets.

• 別名: Endothelin 3, Human and Rat, ET-3, CTCFTYKDKECVYYCHLDIIW
• 実験式（ヒル表記法）: C₁₂₁H₁₆₈N₂₆O₃₃S₄
• CAS番号: 117399-93-6
• 分子量: 2643.04
• MDL番号: MFCD00076378
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated
• 溶解性: 5% acetic acid: 0.5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phopholipase C in fibroblasts expressing ET_A receptors.

Attenuates thrombin-evoked aggregation of human platelets. A potent stimulator of interleukin-6 production by endothelial cell lines. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
Stimulator of interleukin-6 production by endothelial cell lines

Product does not compete with ATP.

Reversible: no

包装

Yes

シーケンス

H-Cys¹-Thr-Cys³-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Tyr-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

物理的形状

Supplied as a trifluoroacetate salt. Sold on the basis of peptide content.

調製ノート

Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with cold water to 5% acetic acid and 0.5 mg/ml peptide.

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

その他情報

Gresser, O., et al. 1996. Biochem. Biophys. Res. Commun.224, 169.
Astarie-Dequeker, C., et al. 1995. Br. J. Pharmacol. 114, 524.
Xin, X., et al. 1995. Endocrinology 136, 132.
Brunner, F., et al. 1992. J. Mol. Cell. Cardiol.24, 1291.
Lamers, J.M., et al. 1992. Mol. Cell. Biochem. 116, 59.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable