05-23-0101

Angiotensin II, Human

Plays an important role in the regulation of blood pressure.

• 別名: Angiotensin II, Human, DRVYIHPF, ang II
• 実験式（ヒル表記法）: C₅₀H₇₁N₁₃O₁₂
• CAS番号: 4474-91-3
• 分子量: 1046.18
• UNSPSCコード: 12352202
• NACRES: NA.77

特性

• 由来生物: human
• 品質水準: 100
• 無菌性: non-sterile
• アッセイ: ≥98% (HPLC)
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• テクニック: cell based assay: suitable
• 色: white to off-white
• 溶解性: 5% acetic acid: 1 mg/mL; water: 1 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
• InChI: 1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41?/m0/s1
• InChI Key: CZGUSIXMZVURDU-GYGDIBSWSA-N
• 遺伝子情報: human ... ACE2(59272)

詳細

詳細

Research area: Cell signaling

Cell permeable: no

Primary Target adenylate cyclase activity

Product does not compete with ATP.

Reversible: no

アプリケーション

Angiotensin II, Human has been used to induce fibrosis in mice to evaluate the impact of fibroblast loss on cardiac function after injury. It has also been used to induce abdominal aortic aneurysm (AAA) progression in mice.

生物化学的／生理学的作用

Angiotensin II is a crucial component of the Renin-Angiotensin System (RAS). It plays a vital role in vasoconstriction, regulating blood pressure, and controlling fluid balance by influencing the retention of sodium and water in the renal tubules. Furthermore, Angiotensin II stimulates the release of aldosterone from the adrenal gland, contributing to the maintenance of fluid and electrolyte balance regulation. Angiotensin II also promotes inflammation and tissue injury. It Inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II also activates JAK2 in smooth muscle cells, as well as several kinases including p125FAK, cytosolic calcium-dependent tyrosine kinase, and p60c-src in various cell types. In vascular smooth muscle cells, it activates ERK1/2, JNK, and p38 MAP Kinase.

包装

Yes

警告

Toxicity: Standard Handling (A)

シーケンス

H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

その他情報

Zhu, M., et al. 2000. J. Neurophysiol.84, 2494.
Natarajan, R., et al. 1999. Hypertension 33, 378.
Mazzolai, L., et al. 1998. Hypertension 31, 1324.
Earp, H.S., et al. 1995. J. Biol. Chem. 270, 28440.
Ishida, M., et al. 1995. Circ. Res. 77, 1053.
Vyas, S.J., and Jackson, E.K. 1995. J. Pharmacol. Exp. Ther. 273, 768.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable