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Merck

P-055

Supelco

Propranolol hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

実験式(ヒル表記法):
C16H21NO2·HCl
CAS番号:
分子量:
295.80
EC Number:
UNSPSCコード:
41116107
NACRES:
NA.24

グレード

certified reference material

形状

liquid

特徴

Snap-N-Spike®/Snap-N-Shoot®

包装

ampule of 1 mL

メーカー/製品名

Cerilliant®

濃度

1.0 mg/mL in methanol (as free base)

テクニック

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

アプリケーション

clinical testing

フォーマット

single component solution

保管温度

−20°C

SMILES記法

Cl.CC(C)NCC(O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

InChI Key

ZMRUPTIKESYGQW-UHFFFAOYSA-N

遺伝子情報

詳細

A certified reference solution suitable for use as starting material in calibrators and controls for LC/MS or GC/MS testing methods in clinical and diagnostic testing, urine drug testing, forensic analysis, or clinical toxicology. Propranolol is a sympatholytic non-selective beta blocker used to treat a variety of medical conditions including hypertension, anxiety and panic. The drug is sold under numerous brand names such as Inderal®, Avlocardyl, Deralin, and Dociton.

アプリケーション

<ul>
<li><strong>Propranolol hydrochloride solution for infantile hemangioma:</strong>Liposomal formulations of propranolol hydrochloride have been developed for the treatment of infantile hemangioma, offering a targeted therapeutic approach in pediatric dermatology (Nifli et al., 2024).</li>
<li><strong>Propranolol hydrochloride:</strong> Research on the percutaneous absorption of solvent-deposited propranolol hydrochloride across different skin layers provides insights into its properties like it can be used as a function of dose and ionization state and as a calibration standard (Tonnis et al., 2024).</li>
</ul>

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Inderal is a registered trademark of Cranford Pharmaceuticals, LLC
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

ピクトグラム

FlameSkull and crossbonesHealth hazard

シグナルワード

Danger

危険有害性情報

危険有害性の分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

ターゲットの組織

Eyes

保管分類コード

3 - Flammable liquids

WGK

WGK 1

引火点(°F)

49.5 °F - closed cup

引火点(℃)

9.7 °C - closed cup


適用法令

試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。

消防法

第4類:引火性液体
アルコール類
危険等級II

Jan Code

P-055-1ML:4548174003923
P-055-CC:


試験成績書(COA)

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Amy C Arnold et al.
Neurology, 80(21), 1927-1933 (2013-04-26)
To determine the effect of low-dose propranolol on maximal exercise capacity in patients with postural tachycardia syndrome (POTS). We compared the effect of placebo vs a single low dose of propranolol (20 mg) on peak oxygen consumption (VO2max), an established
[Hemangioma can be effectively treated with propranolol. Experiences from twelve cases, with promising results and few side effects].
Carl Johan Rosenkvist et al.
Lakartidningen, 110(19-20), 942-945 (2013-06-12)
Practice gaps. Propranolol to treat hemangiomas of infancy: safety and side effect recognition.
Jonathan A Dyer
JAMA dermatology, 149(4), 485-486 (2013-05-30)
Patricia Mabel Pintos et al.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion, 65(1), 39-51 (2013-06-12)
Propranolol (P) treatment exerts a preventive effect against the detrimental consequences to bone status in mildly chronically food-restricted growing rats (NGR) by an increment in cortical bone and by improving its spatial distribution. To study the effect of beta-blocker on
Jun Zhang et al.
Rapid communications in mass spectrometry : RCM, 27(7), 731-737 (2013-03-16)
Multiplexed liquid chromatography (LC) coupled with multiple-injection-chromatogram acquisition has emerged as the method of choice for high-speed discovery bioanalysis, because it significantly reduces injection-to-injection cycle time while maintaining the chromatography quality. Historically, systems utilizing this approach had been custom built

資料

This study compares the use of SPME LC Tips to dried blood spots (DBS) in terms of extraction efficiency and detection limits of target analytes from whole blood.

This article highlights the impact that sample matrix effects can have on LC/MS response and discusses two novel approaches to reduce it.

プロトコル

LC/MS/MS Analysis of Drugs in Plasma on Ascentis® Express C18 after Extraction using SPME LC Tips

ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.

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