H-134

Hydroxynorketamine hydrochloride solution

1.0 mg/mL in methanol (as free base), certified reference material, ampule of 1 mL, Cerilliant^®

• 実験式（ヒル表記法）: C₁₂H₁₄ClNO₂ · HCl
• 分子量: 276.16
• UNSPSCコード: 41116107
• NACRES: NA.24

特性

• グレード: certified reference material
• 品質水準: 300
• フォーム: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: forensics and toxicology
• フォーマット: single component solution
• 保管温度: −20°C

詳細

詳細

Hydroxynorketamine (HNK), or 6-hydroxynorketamine, is a secondary metabolite of the anesthetic, dissociative, and antidepressant drug ketamine. It is formed by hydroxylation of the intermediate norketamine. This certified Snap-N-Spike^® solution is suitable for numerous GC/MS or LC/MS applications in forensic analysis, urine drug testing, clinical toxicology, and clinical or diagnostic testing. Ketamine, sold as Ketanest, Ketaset and Ketalar, is an NMDA receptor antagonist used for the induction and maintenance of general anesthesia in human and veterinary medicine. The drug is often abused at clubs, raves, or parties for its noted hallucingenic and dissociative properties and prescribed by some doctors as an off-label treatment for depression.

アプリケーション

• Hydroxynorketamine HCl for neuropharmacological research: Hydroxynorketamine hydrochloride, a novel NMDA receptor modulator, has shown potential in enhancing synaptic plasticity. This compound provides a promising avenue for exploring neuroprotective strategies in neuropharmacological studies (Fountoulakis et al., 2023).
• Antidepressant effects of Hydroxynorketamine HCl in preclinical studies: Studies have demonstrated that Hydroxynorketamine hydrochloride exhibits significant antidepressant effects, making it a valuable candidate for treatment-resistant depression research. This compound′s unique mechanism involving the NMDA receptor highlights its potential in psychiatric treatments (Gilbert et al., 2021).
• Synaptic plasticity research using Hydroxynorketamine hydrochloride: Hydroxynorketamine hydrochloride′s role in modulating synaptic plasticity has been studied, emphasizing its therapeutic potential in neurodegenerative diseases and cognitive disorders. This research underlines the importance of Hydroxynorketamine as a tool in understanding the complexities of synaptic functions (Evans et al., 2018).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P260 - P280 - P301 + P310 + P330 - P308 + P311 - P370 + P378 - P403 + P233
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup