D-034

デキストロルファン 酒石酸塩 溶液

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

• 実験式（ヒル表記法）: C₂₁H₂₉NO₇
• CAS番号: 143-98-6
• 分子量: 407.46
• EC Number: 200-659-6
• MDL番号: MFCD00151495
• UNSPSCコード: 41116107
• PubChem Substance ID: 329798600
• NACRES: NA.24

特性

• グレード: certified reference material
• 形状: liquid
• 特徴: Snap-N-Spike^®/Snap-N-Shoot^®
• 包装: ampule of 1 mL
• メーカー／製品名: Cerilliant^®
• 濃度: 1.0 mg/mL in methanol (as free base)
• テクニック: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• アプリケーション: forensics and toxicology
• フォーマット: single component solution
• 保管温度: −20°C
• SMILES記法: O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34
• InChI: 1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m11/s1
• InChI Key: RWTWIZDKEIWLKQ-XCPWPWHNSA-N

詳細

詳細

A Snap-N-Spike^® Reference Solution suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, P450 trials, or pharmaceutical research. Dextrorphan is a primary metabolite of dextromethorphan in blood. Dextromethorphan, an active ingredient in many over-the-counter cold and cough medicines, is used recreationally as a hallucinogen with effects similar to ketamine and phencyclidine (PCP).

アプリケーション

• Anti-Persister Activity Against Borrelia burgdorferi: Dextrorphan tartrate was evaluated for its anti-persister activity against Borrelia burgdorferi, demonstrating potential as an effective agent in the treatment of persistent Lyme disease infections. This research underscores its pharmacodynamic relevance and encourages further exploration in neuropharmacological contexts (Feng et al., 2015).


• High-Performance Liquid Chromatography in Pharmacokinetics: Dextrorphan tartrate was used in a sensitive assay involving high-performance liquid chromatography for the detection of metoprolol and its major metabolite in human plasma. This method highlights its importance as an analytical standard in pharmacokinetic studies, aiding in the understanding of drug metabolism and disposition (Mistry et al., 1998).


• Opioid Receptor Binding: The interaction of dextrorphan tartrate with opioid receptors was examined, showing that it binds to opioid receptors in guinea-pig brain membranes and acts as an antagonist in myenteric plexus. This research supports its utility in opioid receptor studies, particularly in examining opioid antagonistic properties (Goldstein & Naidu, 1990).

法的情報

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS02,GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H225,H301 + H311 + H331,H370
• 注意書き: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危険有害性の分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• ターゲットの組織: Eyes
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 1
• 引火点(°F): 49.5 °F - closed cup
• 引火点(℃): 9.7 °C - closed cup