860654P

sphinganine (d17:0)

Avanti Research^™ - A Croda Brand 860654P, powder

• 別名: D-erythro-sphinganine (C17 base)
• 実験式（ヒル表記法）: C₁₇H₃₇NO₂
• CAS番号: 32164-02-6
• 分子量: 287.48
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• フォーム: powder
• 包装: pkg of 1 × 10 mg (860654P-10mg); pkg of 1 × 5 mg (860654P-5mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 860654P
• 脂質タイプ: sphingolipids
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCC
• InChI: 1S/C17H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(20)16(18)15-19/h16-17,19-20H,2-15,18H2,1H3/t16-,17+/m0/s1
• InChI Key: KFQUQCFJDMSIJF-DLBZAZTESA-N

詳細

詳細

Sphinganine (d17:0), also referred to as dihydrosphingosine, is devoid of double bond. Decarboxylating condensation of serine with palmitoyl-CoA yield keto intermediate(2-oxosphinganine), which is then reduced by NADPH to form Sphinganine.

アプリケーション

Sphinganine (d17:0) has been used in liquid chromatography-mass spectrometry (LC-MS) for the in-situ estimation of dihydrosphingosine utilization in N-(4-hydroxyphenyl)retinamide (4-HPR) resistant leukemia cells. It is suitable for use as an internal standard in metabolomic study.

生物化学的／生理学的作用

Sphinganine (SPA) or D-erythro-sphinganine is involved in sphingolipid biosynthesis pathway. It acts as a precursor for ceramide. SPA has an ability to inhibit the activity of protein kinase c. SPA accumulation enables fumonisin B1 to stimulate apoptosis. It also has an ability to block cholesterol transport in Niemann-Pick Type C (NPC) disease.

包装

5 mL Amber Glass Screw Cap Vial (860654P-10mg)

5 mL Amber Glass Screw Cap Vial (860654P-5mg)

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3