800816C

16:0 DG

1,2-dipalmitoyl-sn-glycerol, chloroform

• 別名: 1,2-dihexadecanoyl-sn-glycerol; DG(16:0/16:0/0:0)
• 実験式（ヒル表記法）: C₃₅H₆₈O₅
• CAS番号: 30334-71-5
• 分子量: 568.91
• MDL番号: MFCD00042874
• UNSPSCコード: 12352211
• NACRES: NA.25

特性

• アッセイ: >99% (TLC)
• フォーム: liquid
• 包装: pkg of 1 × 5 mL (800816C-10mg); pkg of 1 × 5 mL (800816C-25mg)
• メーカー／製品名: Avanti Research^™ - A Croda Brand 800816C
• 濃度: 2 mg/mL (800816C-10mg); 5 mg/mL (800816C-25mg)
• 脂質タイプ: neutral lipids; neutral glycerides
• 輸送温度: dry ice
• 保管温度: −20°C
• SMILES記法: O(C(COC(=O)CCCCCCCCCCCCCCC)CO)C(=O)CCCCCCCCCCCCCCC
• InChI: 1S/C35H68O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(37)39-32-33(31-36)40-35(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33,36H,3-32H2,1-2H3
• InChI Key: JEJLGIQLPYYGEE-UHFFFAOYSA-N

詳細

詳細

16:0 DG (1,2-dipalmitoyl-sn-glycerol) is a diacylglycerol with longer acyl chains.

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

アプリケーション

16:0 DG has been used to spike brain samples for mass spectrometric analysis. It may be used as diacyl-glycerol source in diacylglycerol O-acyltransferase 1 (DGAT1) enzyme assay in human leukemic K562 cells and in Golgi-like liposomes reconstitution.

生物化学的／生理学的作用

16:0 DG (1,2-dipalmitoyl-sn-glycerol) fails to prevent the late fission events in Golgi membrane.

包装

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800816C-10mg)

30 mL Amber Narrow Mouth Glass Bottle with Screw Cap (800816C-25mg)

保管および安定性

Diacylglycerols are conveniently stored in chloroform solutions in glass vials with PTFE-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.

その他情報

Delivery to cells:
Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.

Effective concentration:
Most biological responses saturate at 20 to 250 μM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.

Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.

法的情報

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全性情報

• ピクトグラム: GHS06,GHS08
• シグナルワード: Danger
• 危険有害性情報: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 注意書き: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• 危険有害性の分類: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• ターゲットの組織: Central nervous system, Liver,Kidney
• WGK: WGK 3