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About This Item
実験式(ヒル表記法):
C23H28N2O11
分子量:
508.48
MDL番号:
UNSPSCコード:
12352108
PubChem Substance ID:
NACRES:
NA.22
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アッセイ
>90%
フォーム
solid or viscous liquid
反応適合性
reactivity: amine reactive
reagent type: cross-linking reagent
reactivity: thiol reactive
官能基
NHS ester
ポリマー構造
shape: linear
functionality: heterobifunctional
輸送温度
ambient
保管温度
−20°C
SMILES記法
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCON2C(C(C=CC=C3)=C3C2=O)=O
関連するカテゴリー
特徴および利点
Phthalimidooxy-dPEG®4-NHS ester allows introduction of an oxyamine function onto a target molecule for cross-linking proteins or for creating stable conjugates with the target molecule. The oxyamine function is protected by a phthalimido protecting group on one end of the spacer arm, and the spacer is installed on the target molecule with the amine-reactive N-hydroxysuccinimide (NHS) group on the other end of the spacer. The single molecular weight dPEG® spacers have precise length for spatial control. They are hydrophilic and non-immunogenic. The dPEG® spacers improve water solubility and reduce aggregation and precipitation of proteins. The phthalimido protecting group can be removed using hydrazine. The oxyamine group exposed after deprotection can be reacted with an aldehyde- or ketone-containing molecule to form an oxime bond linking the two molecules. These reagents can be used with any protein, peptide, or small molecule that has a free amine.
法的情報
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
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