936413

Fmoc-Val-Cit-OH

≥95%

• 別名: (S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)-5-ureidopentanoicacid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-L-ornithine (ACI), L-Ornithine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N⁵-(aminocarbonyl)-, L-Ornithine, N⁵-(aminocarbonyl)-N²-[N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl]- (ZCI)
• 実験式（ヒル表記法）: C₂₆H₃₂N₄O₆
• CAS番号: 159858-21-6
• 分子量: 496.56
• MDL番号: MFCD28139060
• UNSPSCコード: 12352209
• NACRES: NA.22

特性

• 品質水準: 100
• アッセイ: ≥95%
• 形状: powder or crystals
• 色: white to beige
• 保管温度: 2-8°C
• SMILES記法: C(OC(N[C@H](C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)C(C)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2
• InChI: InChI=1S/C26H32N4O6/c1-15(2)22(23(31)29-21(24(32)33)12-7-13-28-25(27)34)30-26(35)36-14-20-18-10-5-3-8-16(18)17-9-4-6-11-19(17)20/h3-6,8-11,15,20-22H,7,12-14H2,1-2H3,(H,29,31)(H,30,35)(H,32,33)(H3,27,28,34)/t21-,22-/m0/s1
• InChI Key: ZJLNQOIFTYLCHC-VXKWHMMOSA-N

詳細

アプリケーション

This is a cathepsin cleavable linker used in bioconjugation, specifically in the construction of antibody drug conjugates (ADC & Bioconjugation).

特徴および利点

Fmoc-Val-Cit-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADC). The Val-Cit is specifically cleaved by cathepsin B.

その他情報

ADC & Bioconjugation

Chemical Biology Tools

http://pubs.rsc.org/en/Content/ArticleLanding/2011/MB/C0MB00074D#!divAbstract

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable