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品質水準
保管温度
−20°C
アプリケーション
NanoFabTx™ Biotin Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of biotin-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with biotin groups using extrusion and microfluidics are also included. The synthesized biotin-functionalized liposomes enable 1) selectively targeting cells which overexpress avidin-receptors (i.e. HeLa cells) and 2) the conjugation of avidin-tagged antibodies or proteins (i.e. Streptavidin) to the liposomes surface for immunotherapy applications and multi-targeting or multi-type cargo delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with biotin groups using extrusion and microfluidics are also included. The synthesized biotin-functionalized liposomes enable 1) selectively targeting cells which overexpress avidin-receptors (i.e. HeLa cells) and 2) the conjugation of avidin-tagged antibodies or proteins (i.e. Streptavidin) to the liposomes surface for immunotherapy applications and multi-targeting or multi-type cargo delivery.
特徴および利点
- A ready-to-use nanoformulation lipid blend for the synthesis of biotin-functionalized liposomes
- Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible liposomes
- Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
- Lipid mix optimized for avidin-tagged protein or antibody conjugation and small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
For more information, please refer to the protocol under the Protocol section of this page.
法的情報
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
保管分類コード
11 - Combustible Solids
WGK
WGK 3
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
932612-25MG-PW:
932612-BULK:
932612-25MG:
932612-100MG-PW:
932612-100MG:
932612-VAR:
最新バージョンのいずれかを選択してください：
Eliana B Souto et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 128, 27-35 (2018-11-26)
CAB51, a compact antibody against human epithelial growth receptor 2 (HER2, ErbB2), has been linked to cationic Solid Lipid Nanoparticles (SLN) via streptavidin-biotin interaction and their targeting potential evaluated against breast cancer cells. The amount of streptavidin and biotinylated antibody
Nina Pedersen et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 62(2), 155-162 (2005-11-18)
Cationic solid lipid nanoparticles (SLN) have recently been suggested for non-viral gene delivery, as these particles consist of well tolerated substances, can bind DNA directly via electrostatic interactions and mediate gene transfer in vitro. We here report the development of
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