925039

E7820-PEG₃-NH₂ hydrochloride

• 別名: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-3-(N-(3-cyano-4-methyl-1H-indol-7-yl)sulfamoyl)benzamide hydrochloride, Crosslinker–E3 Ligase ligand conjugate, DCAF15 protein degrader building block
• 実験式（ヒル表記法）: C₂₅H₃₁N₅O₆S · xHCl
• 分子量: 529.61 (free base basis)
• NACRES: NA.22

特性

• ligand: E7820
• 品質水準: 100
• 形状: amorphous powder
• 反応適合性: reactivity: carboxyl reactive; reagent type: ligand-linker conjugate
• 官能基: amine
• 保管温度: 2-8°C

詳細

アプリケーション

Protein degrader builiding block E7820-PEG3-NH₂ hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. This conjugate contains a DCAF15-recruiting ligand E7820 (SML2950 ), a PEG linker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate degrader libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Protein Degrader Building Blocks

Technology Spotlight: DCAF15 Degrader Building Blocks for Targeted Protein Degradation

その他情報

In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

法的情報

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable