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Merck

PRKCG

protein kinase C, gamma

別名:
PKC-gamma, PKCC, PKCG, SCA14
Species:
UniProtKB ID:
遺伝子ID:
  • Human(5582) Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
  • Mouse(18752) protein kinase C, gamma
  • Rat(24681) protein kinase C, gamma
  • Zebrafish(100003514) protein kinase C, gamma
  • dog(484316) protein kinase C, gamma
  • Horse(100062549) protein kinase C, gamma
  • domestic cat(101082196) protein kinase C, gamma
  • domestic guinea pig(100733947) protein kinase C, gamma
  • Domestic Rabbit(100009102) protein kinase C, gamma
  • naked mole-rat(101698346) protein kinase C, gamma
  • cow(282002) protein kinase C, gamma
  • sheep(101116423) protein kinase C, gamma

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Small Molecule - Agonist

製品番号
詳細
Species
オレイン酸, ≥99% (GC),
Species
human

Antibodies

製品番号
詳細
交差性
アプリケーション
Anti-PKCγ Antibody, clone 2B9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human, rat
アプリケーション
affinity binding assay
immunofluorescence

immunohistochemistry

western blot
Anti-PKC gamma Antibody, clone 5F2X3, Rabbit Monoclonal, ,
交差性
mouse, rat
アプリケーション
western blot
Anti-PKCγ (C-term) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
交差性
human, mouse
アプリケーション
ELISA
western blot
Anti-PRKCG antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunohistochemistry
Anti-p-PKCγ (Thr514) Antibody, clone 4F20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human, mouse, rat
アプリケーション
immunohistochemistry
inhibition assay

western blot

Small Molecule - Inhibitor

製品番号
詳細
Species
H-7 二塩酸塩, ≥98% (HPLC),
Species
human
タモキシフェン クエン酸塩, ≥99%,
Species
human
オレイン酸, ≥99% (GC),
Species
human
UCN-01, ≥97% (HPLC), powder,
Species
human
GSK690693, ≥98% (HPLC),
Species
human

Proteins

製品番号
詳細
Species
PKCγ、活性型、GSTタグ融合 ヒト, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human PRKCG,
Species
human