リコンビナント
expressed in baculovirus infected Sf9 cells
品質水準
製品種目
PRECISIO® Kinase
アッセイ
≥70% (SDS-PAGE)
形状
buffered aqueous glycerol solution
比活性
435-589 nmol/min·mg
分子量
~105 kDa
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−70°C
遺伝子情報
human ... PRKCG(5582)
詳細
PKCγ (protein kinase C γ) is a s a serine/threonine kinase belonging to the protein kinase C (PKC) family. PKCγ is mainly present in the central nervous system and is strongly expressed in cerebellar Purkinje cells.
生物化学的／生理学的作用
PKCγ (protein kinase C γ) is involved in cell proliferation, differentiation as well as migration. Mutations in PKCγ are associated with neurodegenerative disease, spinocerebellar ataxia type 14. Single nucleotide polymorphisms in PKCγ are also linked with high risk of osteosarcoma.
物理的形状
50 mM Tris-HCl溶液(pH 7.5、150 mM NaCl、0.25 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF、25%グリセロール含有)。
法的情報
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
カルタヘナ法
カルタヘナ法
Jan Code
K4518-VAR:
K4518-10UG:
K4518-10UG-PW:
K4518-BULK:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Hideyuki Takahashi et al.
Human molecular genetics, 24(2), 525-539 (2014-09-14)
Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C (PKC) γ, a serine/threonine kinase mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as a novel
Ying Zhang et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(12), 12671-12677 (2014-09-26)
The objective of this study was to explore the relationship between single-nucleotide polymorphisms (SNPs) of the protein kinase C gamma (PRKCG) gene and osteosarcoma susceptibility in Chinese Han population. A total of 610 cases of osteosarcoma patients and 610 healthy
M Shamloo et al.
Neuroreport, 10(5), 931-935 (1999-05-13)
Neurons can be preconditioned against ischemic damage by a brief sublethal period of ischemia, applied several days before the second insult. Here we report on changes in the distribution and the levels of protein kinase Cgamma (PKCgamma) in nonconditioned and
J Rennecke et al.
European journal of biochemistry, 242(2), 428-432 (1996-12-01)
13 murine tissues and 12 cell lines were tested for the expression of the novel protein kinase C (PKC) isoenzyme mu. Using two different PKC mu antibodies (sc-639 and P26720), PKC mu was detected in all tissues and cells and
Huading Lu et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 5241-5247 (2015-02-11)
Osteosarcoma is a common malignant tumor, which exists widely in the bone of children and adolescents. Protein kinase C gamma (PRKCG) gene, which encodes γPKC, plays important roles in tumor promotion, cell proliferation, differentiation, and migration. The objective of the
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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