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Safety Information

23258

Sigma-Aldrich

2,2,2-Trichloroethyl chloroformate

purum, ≥98.0% (NT)

Synonym(s):

2,2,2-Trichloroethoxycarbonyl chloride

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About This Item

Linear Formula:
ClCOOCH2CCl3
CAS Number:
17341-93-4
Molecular Weight:
211.86
Beilstein:
970619
EC Number:
241-363-7
MDL number:
MFCD00000810
UNSPSC Code:
12352100
PubChem Substance ID:
329752403
NACRES:
NA.22

vapor pressure

0.06 psi ( 20 °C)

Quality Level

200

grade

purum

Assay

≥98.0% (NT)

refractive index

n20/D 1.471 (lit.)
n20/D 1.471

bp

171-172 °C (lit.)

density

1.539 g/mL at 25 °C (lit.)

functional group

chloro

storage temp.

2-8°C

SMILES string

ClC(=O)OCC(Cl)(Cl)Cl

InChI

1S/C3H2Cl4O2/c4-2(8)9-1-3(5,6)7/h1H2

InChI key

LJCZNYWLQZZIOS-UHFFFAOYSA-N

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Application

2,2,2-Trichloroethyl chloroformate was used as:
  • derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples
  • starting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)
  • reagent during N-demethylation of dextromethorphan
  • protecting group reagent for amines and alcohols

Pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

Signal Word

Danger

Hazard Statements

H314,H331

Hazard Classifications

Acute Tox. 3 Inhalation - Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

23258-VAR:
23258-BULK:
23258-INTR:
23258-100ML:
23258-25ML:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF3814
BCCC2921
BCCB6437
BCBW7361
BCBV8480

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X.S. He et al.
Synthetic Communications, 20, 2177-2177 (1990)
F. Farina et al.
Tetrahedron Letters, 32, 1109-1109 (1991)
M. Imoto et al.
Bulletin of the Chemical Society of Japan, 60, 2205-2205 (1987)
A Dasgupta et al.
Therapeutic drug monitoring, 20(3), 313-318 (1998-06-19)
Mexiletine (Mexitil) is an antiarrhythmic agent used in the treatment of ventricular arrhythmia. The drug has a narrow therapeutic window, and monitoring its serum concentration is recommended. The authors describe a gas chromatography-mass spectrometric (GC/MS) assay of mexiletine using selected
Giampietro Frison et al.
Rapid communications in mass spectrometry : RCM, 19(7), 919-927 (2005-03-05)
A new analytical approach, based on derivatization with 2,2,2-trichloroethyl chloroformate and gas chromatography/mass spectrometry (GC/MS), was investigated for qualitative and quantitative analyses of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples. Sample preparation involved
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