Merck
All Photos(1)

1.04220

Millipore

Guanidinium chloride

LAB

Synonym(s):
Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidine hydrochloride, Guanidinum hydrochloride, Carbamimidoylazanium chloride, Guanidinium chloride
Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
Molecular Weight:
95.53
Beilstein:
3591990
MDL number:
EC Index Number:
200-002-3

Quality Level

potency

655.3-907.1 mg/kg LD50, oral (Rat)
>2000 mg/kg LD50, skin (Rabbit)

pH

4.5-5.5 (20 °C, 100 g/L in H2O)

mp

180-185 °C (lit.)
188 °C

solubility

2150 g/L

density

1.3 g/cm3 (lit.)

bulk density

550‑620 kg/m3

storage temp.

2-30°C

SMILES string

Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

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Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Analysis Note

Assay (perchloric acid titration): ≥ 99.0 %
Identity (IR-spectrum): passes test
pH-value (10 %; water): 4.5 - 5.5
Melting range: 182 - 186
Chloride (calc. on anhydrous substance): 36.1 - 37.1 %

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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