V3628

Vasoactive Intestinal Peptide human, porcine, rat

≥95% (HPLC), powder

• Sinonimo/i: VIP
• Formula empirica (notazione di Hill): C₁₄₇H₂₃₈N₄₄O₄₂S
• Numero CAS: 40077-57-4
• Peso molecolare: 3325.80
• Numero MDL: MFCD00167535
• Codice UNSPSC: 12352200
• ID PubChem: 24900742
• NACRES: NA.32

Proprietà

• Saggio: ≥95% (HPLC)
• Forma fisica: powder
• Solubilità: 1% acetic acid: 0.1%, clear, colorless
• N° accesso UniProt: P01282
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc4c[nH]cn4)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(N)=O
• InChI: 1S/C147H238N44O42S/c1-18-75(12)115(143(231)182-97(56-72(6)7)131(219)174-94(118(156)206)61-108(153)199)189-140(228)106(68-193)186-135(223)102(63-110(155)201)179-132(220)96(55-71(4)5)176-133(221)98(58-81-37-41-84(196)42-38-81)177-126(214)88(33-23-26-49-149)168-124(212)89(34-24-27-50-150)172-141(229)113(73(8)9)187-119(207)76(13)165-122(210)93(47-53-234-17)171-128(216)92(45-46-107(152)198)170-123(211)87(32-22-25-48-148)167-125(213)90(35-28-51-162-146(157)158)169-130(218)95(54-70(2)3)175-127(215)91(36-29-52-163-147(159)160)173-144(232)116(78(15)194)190-137(225)99(59-82-39-43-85(197)44-40-82)178-134(222)101(62-109(154)200)180-136(224)104(65-112(204)205)184-145(233)117(79(16)195)191-138(226)100(57-80-30-20-19-21-31-80)183-142(230)114(74(10)11)188-120(208)77(14)166-129(217)103(64-111(202)203)181-139(227)105(67-192)185-121(209)86(151)60-83-66-161-69-164-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,192-197H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,198)(H2,153,199)(H2,154,200)(H2,155,201)(H2,156,206)(H,161,164)(H,165,210)(H,166,217)(H,167,213)(H,168,212)(H,169,218)(H,170,211)(H,171,216)(H,172,229)(H,173,232)(H,174,219)(H,175,215)(H,176,221)(H,177,214)(H,178,222)(H,179,220)(H,180,224)(H,181,227)(H,182,231)(H,183,230)(H,184,233)(H,185,209)(H,186,223)(H,187,207)(H,188,208)(H,189,228)(H,190,225)(H,191,226)(H,202,203)(H,204,205)(H4,157,158,162)(H4,159,160,163)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1; HEOYHMUESMJFDC-RIWXPGAOSA-N
• Informazioni sul gene: human ... VIP(7432)

Descrizione

Amino Acid Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

Descrizione generale

The vasoactive intestinal peptide (VIP) gene is mapped to human chromosome 6q25.2. This gene encodes a neuropeptide containing 28-amino acid. Vip belongs to the glucagon/secretin superfamily and is conserved along evolution. It is predominantly localized to the central and peripheral nervous systems.

Applicazioni

Vasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.

Vasoactive Intestinal Peptide human, porcine, rat was used as an antigen utilized in absorption purpose for systematic study of nervous system of the chicken proventriculus by using immunohistochemistry and electron microscopy.

Azioni biochim/fisiol

Neuropeptide that is widely distributed in the central and peripheral nervous systems. It is a vasodilator, bronchodilator and smooth muscle relaxant. It modulates the activity of many immune system cell types. It is a mitogen for embryonic sympathetic neurons. Its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells.

VIP (Vasoactive intestinal peptide) possesses anti-inflammatory and immunomodulatory functions. It controls the pathogenesis of rheumatoid arthritis. It is also involved in neuroblastoma differentiation, and pancreatic insulin secretion. Vip exhibits its function through G-protein coupled receptors. Some of the other important actions of VIP is associated with the digestive, respiratory, cardiovascular and reproductive systems.

Vasoactive Intestinal Peptide human, porcine, rat is a neuropeptide synthesize in the central nervous system, which enhances the formation of adenosine 3′,5′-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP also modulates the cholinergic as well as serotonergic neurotransmitter systems.

Nota sulla preparazione

Vasoactive Intestinal Peptide human, porcine, rat dissolves in water at 0.1% in 1% acetic acid to yield a clear, colorless solution.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)