T1580
Anti-TDP-43 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
Sinonimo/i:
Anti-ALS10, Anti-TARDBP, Anti-TARDP43
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About This Item
Codice UNSPSC:
12352203
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen ~43 kDa
Reattività contro le specie
human, mouse, rat
Concentrazione
~1.0 mg/mL
tecniche
immunohistochemistry: 5-10 μg/mL using rat, mouse, and human kidney
indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells
western blot: 1-2 μg/mL using human U2OS cell lysates
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... TARDBP(23435)
Descrizione generale
TDP-43 (TAR DNA binding protein, TARDP) is a 414 amino acid nuclear protein and is a member of the heterogenous nuclear ribonucleoproteins (hnRNPs) family that bind single stranded RNA. It is encoded by the gene mapped to human chromosome 1p36.22. The encoded protein belongs to the family of heterogenous nuclear ribonucleoproteins (hnRNPs) that bind single stranded RNA. TDP-43 is ubiquitously expressed and is characterized with two RNA-recognition motifs and a glycine-rich C-terminal region.
Specificità
Anti-TDP-43 (C-terminal) specifically recognizes human, mouse, and rat TDP-43.
Azioni biochim/fisiol
Heterogeneous nuclear ribonucleoproteins (hnRNPs) play a vital role in generation and processing of RNA, including transcription, splicing, transport and stability. TDP-43 acts as a transcription regulator for human immunodeficiency virus (HIV). Abnormal phosphorylation of TDP-43 at Ser409/410 contributes to the pathology of frontotemporal lobe degeneration subtype (FTLD-U) and amyotrophic lateral sclerosis (ALS).
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Stoccaggio e stabilità
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Esclusione di responsabilità
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Overexpression of heat shock factor 1 maintains TAR DNA binding protein 43 solubility via induction of inducible heat shock protein 70 in cultured cells
Lin PY, et al.
Journal of Neuroscience Research, 94(7), 671-682 (2016)
Miguel Mompeán et al.
Archives of biochemistry and biophysics, 545, 53-62 (2014-01-21)
TDP-43 is a nuclear protein whose abnormal aggregates are implicated in ALS and FTLD. Recently, an Asn/Gln rich C-terminal segment of TDP-43 has been shown to produce aggregation in vitro and reproduce most of the protein's pathological hallmarks in cells
Clara Bruno et al.
Brain communications, 2(2), fcaa133-fcaa133 (2020-10-03)
Loss-of-function mutations in TANK-binding kinase 1 cause genetic amyotrophic lateral sclerosis and frontotemporal dementia. Consistent with incomplete penetrance in humans, haploinsufficiency of TANK-binding kinase 1 did not cause motor symptoms in mice up to 7 months of age in a previous
Yuriko Katsumata et al.
Acta neuropathologica communications, 6(1), 142-142 (2018-12-21)
TAR-DNA binding protein 43 (TDP-43) proteinopathy is a common brain pathology in elderly persons, but much remains to be learned about this high-morbidity condition. Published stage-based systems for operationalizing disease severity rely on the involvement (presence/absence) of pathology in specific
Lindsay A Becker et al.
Nature, 544(7650), 367-371 (2017-04-14)
Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease that is characterized by motor neuron loss and that leads to paralysis and death 2-5 years after disease onset. Nearly all patients with ALS have aggregates of the RNA-binding protein
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