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Merck
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Documenti fondamentali

SRP6586

Sigma-Aldrich

Histone H3 (1-136) human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Sinonimo/i:

Histone H3/I, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/j, Histone H3/k, Histone H3/l

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥95% (SDS-PAGE)

Stato

lyophilized powder

PM

15.5 kDa (1-136 aa)

Confezionamento

pkg of 100 and 250 μg

N° accesso UniProt

P68431

Condizioni di spedizione

dry ice

Temperatura di conservazione

−70°C

Informazioni sul gene

human ... HIST1H3A(8350)

Descrizione generale

The mammalian chromatin is present in nucleosomes, made of histone octamers (H2A,H2B,H3,H4)2. Mammals contain three main classes of histone H3 variants: the replicative histones (H3.1 and H3.2), the replacement histone (H3.3) and the centromeric histone (Cenp-A).

Azioni biochim/fisiol

Histone proteins are basic building blocks of chromatin. Changes in the circulating H3 levels are associated with death in sepsis patients. Post-translational modifications of histone tails control chromatin organization and gene transcription. Trimethylated histone H3 lysine 4 (H3K4me3) is present at actively transcribed genes and it helps in promotion of gene expression. Histone H3K36 trimethylation (H3K36me3) is lost in various cancers and is linked with poor patient outcome. Dimethylated H3K9 (H3K9me2) is mainly present in euchromatin and is linked with repressed promoter areas. Histone methyltransferase G9a is responsible for hypoxic stress-mediated H3K9me2 in mammalian cells.

Stato fisico

Lyophilized powder. Recommended buffer is 50 mM sodium phosphate, pH 7.2, containing 100 mM sodium chloride and 20% glycerol.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
2D217670
1C257670

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Histone H2a full length human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

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Histone H4 full length human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)

Sigma-Aldrich

SRP0178

Histone H4 full length human

Histone H2B human

Sigma-Aldrich

H2167

Histone H2B human

Histone from calf thymus Type III-S

Sigma-Aldrich

H5505

Histone from calf thymus

Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Pfister SX, et al.
Cancer Cell, 28, 557-557 (2015)
Extracellular histone H3 levels are inversely correlated with antithrombin levels and platelet counts and are associated with mortality in sepsis patients.
Wildhagen KC, et al.
Thrombosis Research, 136, 542-542 (2015)
Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin.
Lehnertz B, et al.
Current Biology, 13, 1192-1192 (2003)
Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients.
Zhang L, et al.
American Journal of Nephrology, 30, 505-505 (2009)
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNA.
Arents G and Moudrianakis EN
Proceedings of the National Academy of Sciences of the USA, 90, 10489-10489 (1993)
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