SML1705

Cbz-B3A

≥98% (HPLC)

• Sinonimo/i: (8S)-3,8-Bis[[(1,1-dimethylethoxy)carbonyl]amino]-9-oxo-2,4,10,17-tetraazaoctadec-3-enedioic acid 1-(1,1-dimethylethyl) 18-(phenylmethyl) ester
• Formula empirica (notazione di Hill): C₃₅H₅₈N₆O₉
• Numero CAS: 1884710-81-9
• Peso molecolare: 706.87
• Codice UNSPSC: 12352200
• ID PubChem: 329826030
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C(OCC1=CC=CC=C1)NCCCCCCNC([C@H](CCCN/C(NC(OC(C)(C)C)=O)=N\C(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O
• InChI: 1S/C35H58N6O9/c1-33(2,3)48-30(44)39-26(20-17-23-37-28(40-31(45)49-34(4,5)6)41-32(46)50-35(7,8)9)27(42)36-21-15-10-11-16-22-38-29(43)47-24-25-18-13-12-14-19-25/h12-14,18-19,26H,10-11,15-17,20-24H2,1-9H3,(H,36,42)(H,38,43)(H,39,44)(H2,37,40,41,45,46)/t26-/m; JGEWUYSTHGIDHO-SANMLTNESA-N

Descrizione

Azioni biochim/fisiol

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 1, 2, and 4, which prevents mTORC1 activation.

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling.

Altre note

Light and air sensitive.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable