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SML0409

Sigma-Aldrich

STF-083010

≥98% (HPLC)

Sinonimo/i:

N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

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About This Item

Formula empirica (notazione di Hill):
C15H11NO3S2
Numero CAS:
307543-71-1
Peso molecolare:
317.38
Numero MDL:
MFCD02332975
Codice UNSPSC:
12352200
ID PubChem:
329825404
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

light yellow to yellow-green

Solubilità

DMSO: 5 mg/mL (clear solution)

Temperatura di conservazione

−20°C

Stringa SMILE

OC1=C(/C=N/S(C2=CC=CS2)(=O)=O)C3=C(C=CC=C3)C=C1

InChI

1S/C15H11NO3S2/c17-14-8-7-11-4-1-2-5-12(11)13(14)10-16-21(18,19)15-6-3-9-20-15/h1-10,17H/b16-10+
TVIVJHZHPKNDAQ-MHWRWJLKSA-N

Applicazioni

STF-083010 has been used:
  • in a study to investigate the potential anti-lipotoxic effect of nicotinamide and to elucidate underlying mechanism(s)
  • as IRE1a inhibitor to study its effect on NOS 2 expression and investigate the underlying mechanisms in proinflammatory gene expression in astrocytes
  • to block endogenous XBP1 cleavage for one hour prior to palmitate exposure in order to examine whether inositol?requiring enzyme 1α (IRE1α ) activation is implicated in palmitate cytotoxicity

Azioni biochim/fisiol

STF-083010 is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. STF-083010 inhibits IRE1 endonuclease and mRNA splicing activity in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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3-AP-Me ≥98% (HPLC)

Sigma-Aldrich

SML1055

3-AP-Me

ISRIB ≥98% (HPLC)

Sigma-Aldrich

SML0843

ISRIB

Salubrinal ≥98% (HPLC)

Sigma-Aldrich

SML0951

Salubrinal

PERK Inhibitor I, GSK2606414 GSK2606414 is a cell-permeable, highly potent inhibitor of EIF2AK3/PERK (IC₅₀ = 0.4 nM; [ATP] = 5 µM). Targets PERK in its inactive DFG conformation at the ATP-binding region.

Sigma-Aldrich

516535

PERK Inhibitor I, GSK2606414

Tunicamicina

Sigma-Aldrich

T7765

Tunicamicina

Tauroursodeoxycholic Acid, Sodium Salt Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

Millipore

580549

Tauroursodeoxycholic Acid, Sodium Salt

4-Phenylbutyric acid 99%

Sigma-Aldrich

P21005

4-Phenylbutyric acid

The TLR 4-IRE 1alpha pathway activation contributes to palmitate-elicited lipotoxicity in hepatocytes
Shen C, et al.
Journal of Cellular and Molecular Medicine, 22(7), 3572-3581 (2018)
Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction
Shen C, et al.
Nutrition Research (New York, N.Y.), 40, 40-47 (2017)
Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation
Wheeler MA, et al.
Cell, 176(3), 581-596 (2019)
Carley J S Heck et al.
Molecular pharmacology, 95(2), 183-195 (2018-11-18)
Efavirenz (EFV), a widely used antiretroviral drug, is associated with idiosyncratic hepatotoxicity and dyslipidemia. Here we demonstrate that EFV stimulates the activation in primary hepatocytes of key cell stress regulators: inositol-requiring 1α (IRE1α) and X-box binding protein 1 (XBP1). Following
Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
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