M0418

Melanin

BioReagent, Synthetic, suitable for cell culture

• Numero CAS: 8049-97-6
• Numero CE: 232-473-6
• Numero MDL: MFCD00131581
• Codice UNSPSC: 12352209
• NACRES: NA.75

Proprietà

• Origine biologica: synthetic
• Nome Commerciale: BioReagent
• Saggio: ≥97% (TLC)
• Stato: powder
• tecniche: cell culture | mammalian: suitable
• Solubilità: 1 N NH₄OH: 20 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: [nH]1c2c3c(c4c5c([nH]c4)c([c]([c](c5c3c1)=O)=O)C)[c]([c](c2C)=O)=O
• InChI: 1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3; XUMBMVFBXHLACL-UHFFFAOYSA-N

Descrizione

Descrizione generale

Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.

Applicazioni

Melanin has been used:

• to incubate normal human keratinocytes for Masson-Fontana staining
• as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
• as an absorber to mimic human skin or melanocytic nevi and melanoma

Azioni biochim/fisiol

Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.

Nota sulla preparazione

Prepared by oxidation of tyrosine with hydrogen peroxide.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)