M0418
Melanin
BioReagent, Synthetic, suitable for cell culture
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About This Item
Prodotti consigliati
Origine biologica
synthetic
Nome Commerciale
BioReagent
Saggio
≥97% (TLC)
Stato
powder
tecniche
cell culture | mammalian: suitable
Solubilità
1 N NH4OH: 20 mg/mL
Temperatura di conservazione
−20°C
InChI
1S/C18H10N2O4/c1-5-13-9-7(3-19-13)12-10-8(11(9)17(23)15(5)21)4-20-14(10)6(2)16(22)18(12)24/h3-4,19-20H,1-2H3
XUMBMVFBXHLACL-UHFFFAOYSA-N
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Descrizione generale
Melanin is a distinctive class of pigment found in animals, plants, bacteria, and fungi. It is an amorphous polymer formed by the polymerization of phenolic and indolic compounds.
Applicazioni
Melanin has been used:
- to incubate normal human keratinocytes for Masson-Fontana staining
- as a standard in the determination of melanin content in normal human epidermal melanocytes and immortalized human keratinocytes
- as an absorber to mimic human skin or melanocytic nevi and melanoma
Azioni biochim/fisiol
Melanin plays a role in camouflage and energy harvesting. It also helps in protection against ionizing UV radiations, protection against biotic factors such as host defense against pathogens, and abiotic factors like heat, cold and osmotic stress. Melanin acts as a potent cation chelator and is a component of several photoprotective creams as it facilitates free radical scavenging activity. Melanin may be useful as a photo protectant in cell culture.
Nota sulla preparazione
Prepared by oxidation of tyrosine with hydrogen peroxide.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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I clienti hanno visto anche
Michael Waisberg et al.
PloS one, 7(1), e29493-e29493 (2012-01-14)
Malaria has had the largest impact of any infectious disease on shaping the human genome, exerting enormous selective pressure on genes that improve survival in severe malaria infections. Modern humans originated in Africa and lost skin melanization as they migrated
Naira V Margaryan et al.
International journal of molecular sciences, 17(3), 418-418 (2016-03-25)
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Li Ni-Komatsu et al.
Molecular pharmacology, 74(6), 1576-1586 (2008-09-20)
A series of quinolines, including chloroquine and quinine, were identified as potent pigmentation inhibitors through screening a compound library in murine melanocytes. Structure-activity relationship analysis indicated that 4-substituted amino groups with a tertiary amine side chain, such as chloroquine, were
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