SML0085

A-967079

≥98% (HPLC)

• Sinonimo/i: (1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-one oxime
• Formula empirica (notazione di Hill): C₁₂H₁₄FNO
• Numero CAS: 1170613-55-4
• Peso molecolare: 207.24
• Numero MDL: MFCD20488058
• Codice UNSPSC: 12352200
• ID PubChem: 329825146
• NACRES: NA.25

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to tan
• Solubilità: DMSO: ≥12 mg/mL
• Ideatore: Abbott
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCC(=N/O)\C(C)=C\c1ccc(F)cc1
• InChI: 1S/C12H14FNO/c1-3-12(14-15)9(2)8-10-4-6-11(13)7-5-10/h4-8,15H,3H2,1-2H3/b9-8+,14-12+; HKROEBDHHKMNBZ-CHBKHGQFSA-N

Descrizione

Descrizione generale

A-967079 prevents neuropathic and inflammatory pain. It reduces cold allodynia, which is produced by nerve injury.

Applicazioni

A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Azioni biochim/fisiol

A-967079 is a potent and selective antagonist of Transient Receptor Potential Anykrin 1 (TRPA1) with IC₅₀′s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and minimal or no activity at other TRP channels or G-protein-coupled receptors, enzymes, transporters, and ion channels out of 89 tested. A-967079 blocks TRPA1 activation in human and rat cell lines and has been shown to reduce the responses of wide dynamic range (WDR) and nociceptive specific (NS) neurons to high-intensity mechanical stimulation.

Caratteristiche e vantaggi

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable