SCP0252

Thrombin Substrate, fluorogenic

• Formula empirica (notazione di Hill): C₃₁H₄₂N₇O₇
• Peso molecolare: 624.71
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Saggio: ≥95% (HPLC)
• Stato: lyophilized
• Composizione: Peptide Content, ≥80%
• Condizioni di stoccaggio: protect from light
• Temperatura di conservazione: −20°C

Descrizione

Amino Acid Sequence

BOC-Val-Pro-Arg-AFC

Descrizione generale

Thrombin has procoagulant and anticoagulant properties. It also has chemotactic and mitogenic effects. Thrombin triggers the growth of mammalian cells, fibroblasts and macrophage- like tumor cell lines. It regulates brain development. Thrombin plays an important role in hemostasis and thrombosis. It is associated with mast cell degranulation along with the release of histamine and enhances the production of IL-1 (interleukin-1) by activated macrophages. Thrombin stimulates vascular permeability and transendothelial cell migration by neutrophils.

Applicazioni

Thrombin is a serine protease involved in the coagulation cascade wherein it converts fibrinogen into fibrin. Thrombin may be detected (assayed) using peptides that contain the VPR sequence such as the fluorogenic substrates Boc-VPR-AFC, Boc-Val-Pro-Arg-7-AMC and the chromogenic substrate Boc-Val-Pro-Arg-pNA. These substrates may also be useful to detect other serine proteases.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable