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SBR00015

Sigma-Aldrich

AEBSF Ready Made Solution

Sinonimo/i:

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C8H10FNO2S · HCl
Numero CAS:
30827-99-7
Peso molecolare:
239.69
Numero MDL:
MFCD00132962
Codice UNSPSC:
12352202
NACRES:
NA.85

Saggio

≥97%

Livello qualitativo

200

Forma fisica

liquid

Condizioni di stoccaggio

protect from light

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
WRDABNWSWOHGMS-UHFFFAOYSA-N

Applicazioni

This solution is provided at 100 mM in water. The stock solution may be diluted 1:100 for a 1 mM working concentration. Recommended concentrations for use are 0.1-1.0 mM.

Azioni biochim/fisiol

AEBSF is a specific irreversible serine protease inhibitor. It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. AEBSF is an excellent alternative to available serine protease inhibitors as it offers superior inhibitory activity and much lower toxicological risk.

Altre note

The stability of AEBSF decreases rapidly at higher temperatures and at a pH greater than 7.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study
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