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Documenti fondamentali

SAB4502906

Sigma-Aldrich

Anti-Synaptophysin antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

major synaptic vesicle protein p38, synaptophysin

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 33 kDa

Reattività contro le specie

mouse, rat, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SYP(6855)

Descrizione generale

Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.
Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Synaptophysin.

Immunogen Range: 101-150

Applicazioni

Anti-Synaptophysin antibody produced in rabbit has been used in:
  • immunocytochemistry
  • western blotting
  • immunohistochemistry
Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.

Azioni biochim/fisiol

Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Raccomandato

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Single cell transcriptome analysis of mouse carotid body glomus cells
Zhou T, et al.
The Journal of Physiology, 594(15), 4225-4251 (2016)
X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval
Gordon SL and Cousin MA
The Journal of Neuroscience, 33(34), 13695-13700 (2013)
SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo
Zhang L, et al.
eNeuro, ENEURO-EN0175 (2017)
Synaptophysin expression on circulating tumor cells in patients with castration resistant prostate cancer undergoing treatment with abiraterone acetate or enzalutamide
Pal SK, et al.
Urologic Oncology, 36(4), 162-e1-162-e1 (2018)
Yaoming Wang et al.
Nature medicine, 22(9), 1050-1055 (2016-08-23)
Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling activities mediated by the activation of protease-activated receptor 1 (F2R, also known as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage. Recombinant variants of APC

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