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S8627

Sigma-Aldrich

Sulfacetamide

≥98.0%

Sinonimo/i:

N-(4-Aminobenzenesulfonyl)acetamide, N-(4-Aminophenylsulfonyl)acetamide, N1-Acetylsulfanilamide

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About This Item

Formula empirica (notazione di Hill):
C8H10N2O3S
Numero CAS:
144-80-9
Peso molecolare:
214.24
Beilstein:
981718
Numero CE:
205-640-6
Numero MDL:
MFCD00066501
Codice UNSPSC:
51283901
ID PubChem:
24899803
NACRES:
NA.85

Saggio

≥98.0%

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria
mycoplasma

Modalità d’azione

DNA synthesis | interferes

Stringa SMILE

CC(=O)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
SKIVFJLNDNKQPD-UHFFFAOYSA-N

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Descrizione generale

Chemical structure: sulfonamide

Applicazioni

Sulfacetamide is used to study the treatment of acne and seborrheic dermatitis. It is used to study neonatal chlamydial conjunctivitis and meningococcal conjunctivitis.

Azioni biochim/fisiol

Sulfacetamide is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Confezionamento

100G,500G

Altre note

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317,H335

Classi di pericolo

Skin Sens. 1 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
049M4875V
048M4880V
018M4814V
067M4812V
106M4767V

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SODIUM SULFACETAMIDE FOR SEBORRHEIC DERMATITIS
STEPHEN T. WHELAN
American Journal of Diseases of Children, 71, 724-724 (1955)
Demet Sensoy et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(3), 487-495 (2009-02-19)
The aim of this study was to prepare bioadhesive sulfacetamide sodium (SA) microspheres to increase their residence time on the ocular surface and to enhance their treatment efficacy on ocular keratitis. Microspheres were fabricated by spray drying method using mixture
Rade Injac et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 25(4), 424-431 (2008-03-19)
A separation technique for zinc bacitracin, polymyxin B, oxytetracycline and sulfacetamide in animal feedstuffs by micellar electrokinetic capillary chromatography (MEKC) was developed. The running buffer was 20 mmol l(-1) borate, 20 mmol l(-1) phosphate, pH 8.4, containing 20 mmol l(-1)
E Kremer et al.
Journal of inorganic biochemistry, 100(7), 1167-1175 (2006-04-06)
The synthesis, characterization and comparative biological study of a series of antibacterial copper complexes with heterocyclic sulfonamides were reported. Two kinds of complexes were obtained with the stoichiometries [Cu(L)2] . H2O and [Cu(L)2(H2O)4] . nH2O. They were characterized by infrared
Fatmah A M Al-Omary et al.
Bioorganic & medicinal chemistry, 18(8), 2849-2863 (2010-03-31)
A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities. Compounds 22, 33-37, 39-43, and 45 proved to be active DHFR inhibitors with IC(50) range of 0.4-1.0microM. Compound 18 showed
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