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S8751

Sigma-Aldrich

Sulfaguanidine

Sinonimo/i:

4-Amino-N-(aminoiminomethyl)benzenesulfonamide, 4-Amino-N-guanylbenzenesulfonamide

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About This Item

Formula empirica (notazione di Hill):
C7H10N4O2S
Numero CAS:
57-67-0
Peso molecolare:
214.24
Beilstein:
2695326
Numero CE:
200-345-9
Numero MDL:
MFCD00038136
Codice UNSPSC:
51283914
ID PubChem:
24899810
NACRES:
NA.85

Origine biologica

synthetic (Organic)

Livello qualitativo

200

Stato

powder

Colore

white to off-white

Solubilità

1 M HCl: soluble 50 mg/mL

Spettro attività antibiotica

Gram-negative bacteria
Gram-positive bacteria

Modalità d’azione

DNA synthesis | interferes
enzyme | inhibits

Stringa SMILE

NC(=N)NS(=O)(=O)c1ccc(N)cc1

InChI

1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
BRBKOPJOKNSWSG-UHFFFAOYSA-N

Informazioni sul gene

human ... F2(2147) , PRSS1(5644)

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Categorie correlate

Descrizione generale

Chemical structure: sulfonamide

Applicazioni

Sulfaguanidine is used to block the synthesis of folic acid. It is used to study its effect on microsporidial growth and host cell viability.

Azioni biochim/fisiol

Sulfaguanidine is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. Sulfaguanidine is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Altre note

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
SLBQ1293V
SLBD5155V
098K0683
026K0679
030K0629

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R F Cross et al.
Journal of chromatography. A, 929(1-2), 113-121 (2001-10-12)
Two electrically neutral analytes previously observed to be separated from the neutral marker in capillary zone electrophoresis (CZE) experiments [sulphanilamide (SAA) and sulphaguanidine (SGW)] have been examined to determine the basis for separation. The degree of separation increases markedly with
L S Wan et al.
Journal of microencapsulation, 12(4), 417-423 (1995-07-01)
Microspheres were formed when a solution of cellulose phthalate was extruded into 30% glacial acetic acid solution. Sulphonamides entrapped in such microspheres leached into the hardening solution because they dissolved freely in the acetic acid solution. This resulted in poor
T W Wong et al.
Journal of microencapsulation, 19(4), 511-522 (2002-10-25)
The potential application of pectin as a matrix polymer for making microspheres by an emulsification technique was explored, and the drug release property of these pectinate microspheres containing drug cores of varying aqueous solubilities: sulphanilamide, sulphaguanidine and sulphathiazole, was investigated
Alan D Gift et al.
Journal of pharmaceutical and biomedical analysis, 43(1), 14-23 (2006-08-03)
A moisture sorption gravimetric analyzer has been combined with a Raman spectrometer to better understand the various modes of water-solid interactions relevant to pharmaceutical systems. A commercial automated moisture sorption balance was modified to allow non-contact monitoring of the sample
K Nakanishi et al.
Journal of pharmacobio-dynamics, 13(12), 760-765 (1990-12-01)
The influence of suppository bases and adjuvants on the release rate of drugs and the absorption of non-absorbable drugs such as sulfanilic acid (SA) and sulfaguanidine (SG), was investigated following the rectal administration of suppositories. The suppository bases used were
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