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S1688

Sigma-Aldrich

SR 57227A

solid

Sinonimo/i:

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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About This Item

Formula empirica (notazione di Hill):
C10H14ClN3 · HCl
Numero CAS:
77145-61-0
Peso molecolare:
248.15
Numero MDL:
MFCD01756430
Codice UNSPSC:
12352200
ID PubChem:
24278109
NACRES:
NA.77

Forma fisica

solid

Colore

white

Solubilità

H2O: soluble 9 mg/mL

Stringa SMILE

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H
FUMINTAAUJUVMP-UHFFFAOYSA-N

Informazioni sul gene

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

Applicazioni

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Azioni biochim/fisiol

SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.
Potent and selective 5-HT3 serotonin receptor agonist.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301,H315,H319,H335

Classi di pericolo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Taha Gholipour et al.
Seizure, 19(1), 17-22 (2009-11-28)
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the
Qiao Jun Zhang et al.
Brain research, 1384, 69-79 (2011-02-05)
In the present study, effect of SR 57227A, a selective 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist, on the firing activity of pyramidal neurons in the medial prefrontal cortex (mPFC) was studied in normal rats and rats with 6-hydroxydopamine lesions of the substantia
M Poncelet et al.
Journal of neural transmission. General section, 102(2), 83-90 (1995-01-01)
We have investigated the effect of SR 57227A, a selective 5-HT3 receptor agonist which crosses the blood brain barrier, on three rodent models in which antidepressants are active. In the forced swimming test, SR 57227A dose-dependently reduced the duration of
Marlies Oostland et al.
The Journal of physiology, 589(Pt 20), 4837-4846 (2011-09-01)
The serotonin 5-HT(3) receptor is the only ligand-gated ion channel activated by serotonin and is expressed by GABAergic interneurons in many brain regions, including the cortex, amygdala and hippocampus. Furthermore, 5-HT(3) receptors are expressed by glutamatergic Cajal-Retzius cells in the
X Liang et al.
Synapse (New York, N.Y.), 29(3), 257-268 (1998-06-23)
The techniques of intracellular recording and single-electrode voltage-clamp were used to study the effect of serotonin (5-HT) and the selective 5-HT3 receptor agonist SR 57227A on N-methyl-D-aspartic acid (NMDA)-evoked responses in pyramidal cells of the rat medial prefrontal cortex (mPFC)
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