O3639

Ondansetron hydrochloride dihydrate

≥98% (HPLC), powder, 5-HT₃serotonin receptor antagonist

• Sinonimo/i: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride, GR 38032F
• Formula empirica (notazione di Hill): C₁₈H₁₉N₃O · HCl · 2H₂O
• Numero CAS: 103639-04-9
• Peso molecolare: 365.85
• Numero MDL: MFCD00374371
• Codice UNSPSC: 12352200
• ID PubChem: 329818907
• NACRES: NA.32

Proprietà

• Nome del prodotto: Ondansetron hydrochloride dihydrate, ≥98% (HPLC), powder
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white
• Solubilità: H₂O: >5 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl[H].[H]O[H].[H]O[H].Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C
• InChI: 1S/C18H19N3O.ClH.2H2O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;;;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H;2*1H2; VRSLTNZJOUZKLX-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR3A(3359)

Descrizione

Applicazioni

Ondansetron hydrochloride dihydrate has been used as a 5-HT₃ antagonist to attenuate rostro ventromedial medulla (RVM)/cholecystokinin (CCK)-induced mechanical hypersensitivity and to block the effects of trichostatin A (TSA) on 5-HT₃ protein.

Azioni biochim/fisiol

5-HT₃ serotonin receptor antagonist

Ondansetron, (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl) methyl] 1,2,3,9-tetrahydro-4H-carbazol-4-one hydrochloride dehydrate acts as a selective 5-hydroxytryptamine type 3 (5-HT3) serotonin receptor antagonist. It is used as an antiemetic to control nausea and vomiting associated with chemotherapy and radiotherapy.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H318,H410
• Consigli di prudenza: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P391
• Classi di pericolo: Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges