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M3324

Sigma-Aldrich

M100907

≥98% (HPLC)

Sinonimo/i:

(R)-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol, MDL100907, Volinanserin

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About This Item

Formula empirica (notazione di Hill):
C22H28FNO3
Numero CAS:
139290-65-6
Peso molecolare:
373.46
Numero MDL:
MFCD00909060
Codice UNSPSC:
12352200
ID PubChem:
329817971
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

off-white to light brown

Solubilità

DMSO: ≥20 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

COc1cccc([C@H](O)C2CCN(CC2)CCc3ccc(F)cc3)c1OC

InChI

1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
HXTGXYRHXAGCFP-OAQYLSRUSA-N

Informazioni sul gene

human ... HTR2A(3356)

Descrizione generale

M100907 blocks the serotonin 2A (5-HT2A) receptors and imposes antidepressant-like effects. It may be used for treating dopaminergic anomalies.

Azioni biochim/fisiol

M100907 is a selective 5-HT2A Antagonist.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Ashley Furr et al.
The international journal of neuropsychopharmacology, 15(9), 1295-1305 (2011-10-20)
Chronic stress is a risk factor for depression, and chronic stress can induce cognitive impairments associated with prefrontal cortical dysfunction, which are also major components of depression. We have previously shown that 5 wk chronic intermittent cold (CIC) stress induced
Kerry A Waters et al.
Behavioural brain research, 228(1), 211-218 (2011-12-23)
The 5-hydroxytryptamine7 (5-HT7) receptor is a G-protein coupled receptor for serotonin that has been implicated in the pathophysiology of psychiatric and neurological disorders including anxiety, depression and schizophrenia. A number of studies have attempted to evaluate the potential role of
Paul J Fletcher et al.
Neuropharmacology, 61(3), 468-477 (2011-03-16)
Previous work has shown that 5-HT(2C) receptor agonists and 5-HT(2A) receptor antagonists reduce impulsive action, as well as the locomotor stimulant effect of psychomotor stimulants. Since psychomotor stimulants also increase impulsive action we examined the effects of the 5-HT(2C) receptor
Jun-Xu Li et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 36(5), 940-949 (2011-01-07)
Serotonergic (5-HT) systems modulate pain, and drugs acting on 5-HT systems are used with opioids to treat pain. This study examined the effects of 5-HT receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in monkeys. Morphine increased
Peter S Talbot et al.
NeuroImage, 59(1), 271-285 (2011-07-26)
Scanning properties and analytic methodology of the 5-HT2A receptor-selective positron emission tomography (PET) tracer 11C-MDL100907 have been partially characterised in previous reports. We present an extended characterisation in healthy human subjects. 64 11C-MDL100907 PET scans with metabolite-corrected arterial input function
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