R0158

RepSox

≥98% (HPLC), solid, TGF-β RI kinase inhibitor

• Sinonimo/i: E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
• Formula empirica (notazione di Hill): C₁₇H₁₃N₅
• Numero CAS: 446859-33-2
• Peso molecolare: 287.32
• Numero MDL: MFCD09037561
• Codice UNSPSC: 51111800
• ID PubChem: 329823975
• NACRES: NA.77

Proprietà

• Nome del prodotto: RepSox, ≥98% (HPLC)
• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
• InChI: 1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22); LBPKYPYHDKKRFS-UHFFFAOYSA-N

Descrizione

Applicazioni

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

Azioni biochim/fisiol

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)‐induced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable